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Intracranial bleeding has been reported in patients treated with REFLUDAN with or without concomitant thrombolytic therapy.
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At the maximum adult dose of 100 mg/day, peak blood levels of 1641 ng/mL and 2441 ng/mL were observed in two patients, respectively.
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Digestive System: Severe unilateral or bilateral swelling of the parotid and submaxillary glands.
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In patients with chronic mild liver impairment (N=10, 8 patients with Child-Pugh scores of 5–6 and 2 patients with Child-Pugh scores of 7–8) who received 50 mg sertraline per day maintained for 21 days, sertraline clearance was reduced, resulting in approximately 3-fold greater exposure compared to age-matched volunteers with no hepatic impairment (N=10). The exposure to desmethylsertraline was approximately 2-fold greater compared to age-matched volunteers with no hepatic impairment.
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Both possession of anabolic steroids and providing them to others has significant legal consequences.
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Depression is linked to complications such as irregular heartbeats, chest pain, a longer recovery time, the need to return to the hospital, and even an increased risk of death.
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