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These transformations take place mainly in the liver. 
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Absorption of isosorbide dinitrate after oral dosing is nearly complete, but bioavailability is highly variable (10% to 90%), with extensive first-pass metabolism in the liver. 
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This symptom is an important milestone, because it is not easy to treat and a common source of disability in late disease. 
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IN THIS ARTICLECrabs OverviewCrabs CausesCrabs SymptomsWhen to Seek Medical CareExams and TestsCrabs TreatmentSelf-Care at HomeMedicationNext StepsFollow-upPreventionOutlookSynonyms and KeywordsAuthors and EditorsCrabs TreatmentSelf-Care at HomeIt is possible to treat crabs with over-the-counter medications. 
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In adults hepatic toxicity has rarely been reported with acute overdoses of less than 10 grams, or fatalities with less than 15 grams. 
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Therefore, one can have primary syphilis without symptoms, or with only brief symptoms that could be overlooked. 
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